https://jjcit.org/paper/132 10.5455/jjcit.71-1615297634 Raed Alazaidah,Mohammed Amin Almaiah,Mo'ath Al-Luwaici Prediction,Machine learning,Multi-label classification,Associative classification,Learning strategies 31 5972 1835 9-Mar.-2021 24-Apr.-2021 5-May-2021 Multi-label classification (MLC) is a very interesting and important domain that has attracted many researchers in the last two decades. Several single-label classification algorithms that belong to different learning strategies have been adapted to handle the problem of MLC. Surprisingly, no Associative Classification (AC) algorithm has been adapted to handle the MLC problem, where AC algorithms have shown a high predictive performance compared with other learning strategies in single-label classification. In this paper, a deep investigation regarding utilizing AC in MLC is presented. An evaluation of several AC algorithms on three multi-label datasets with respect to five discretization techniques revealed that utilizing AC algorithms in MLC is very promising compared with other algorithms from different learning strategies.